Town officials say they have no idea what will fill the empty spaces, but most agree that a retail shop would fare well at the sites.
Chamber of Commerce President Joel Harper said he did not know what would fill the location.
"I would hope that whatever goes in there would be retail-oriented,"he said. "Something that generates traffic, not a University business or office that doesn't create people movement."
Harper said he did not think pizza parlors, coffee shops or T-shirt vendors would be among businesses that would flourish in those spots.
He said bookstores and clothing retailers were more likely to meet with success onFranklin Street.
Alanna Farkas, a sophomore international studies major from Marshall, said she would like to see a sporting goods store move into either location.
"I used to go to Athletic World for all my sports gear," she said. "But since it's closed, I have to drive all over the place. It would be nice to have (a sporting goods store) close to campus."
Justin Eldreth, a senior from West Jefferson, said he would miss both Silent Sam's at 205 E. Franklin St. and Groundhog Tavern at 149 1/2 E. Franklin St. because they were popular hangouts for the men's rugby team.
"I've heard a few guys talking about starting a rugby bar," he said. "It would be cool to have an actual bar themed around the game, not just a place that we sort of took over and claimed as ours."