Gregory, who recently released his memoir, "Callous on My Soul," was welcomed to the stage with a standing ovation.
He then garnered roaring laughter after opening his speech with a personal anecdote about an accidental energy boost.
"I just realized I popped my Viagra pill instead of my ginseng," Gregory said.
His visit was sponsored by The Sonja H. Stone Black Cultural Center and WNCU Jazz Radio 90.7.
The event was a fund-raiser for the cultural center, which is expected to break ground starting in April 2001.
Gregory began using his comedic skills during his military career in the 1950s.
After he was discharged from the military, he gained national attention while performing before a predominantly white audience at Chicago's Playboy Club in 1961.
Audiences have said Gregory is as much an activist as a comedian because of his talent for making people think as well as laugh.
After he achieved his success as a performer, Gregory made a move in American politics.