The Tar Heels tallied goals early from Kamholz and Ramsey.
In the 16th minute, Kluegel sent a corner kick from the right wing that Kamholz headed past Wake goalkeeper Tracy Chao from 6 yards out.
Ramsey's goal came in the 18th minute after Chao saved a shot by forward Meredith Florance. The rebound dribbled over to the left side of the goal, where Ramsey collected it and slid it in.
Those two scores nullified Wake's strategy against the Tar Heels, one very similar to the plan that had worked so successfully in October.
Hoping to limit UNC's scoring chances and squeak out the win with a goal or two of their own, the Deacons came out in a bunker formation, stacking their backfield with five defenders and drawing all of their players back when the Tar Heels had possession.
But Kamholz and Ramsey made that strategy moot.
"What happened today was we stuck a couple early, and when that happened, they couldn't sit back in their bunker," Dorrance said. "They had to come out. They had to play a regular system."
Sophomore midfielder Leslie Gaston came off the bench to record UNC's third goal in the 50th minute, tapping in a shot from the right side off touch passes from Anne Remy and Kluegel.
Ramsey added her second goal off an assist from junior Danielle Borgman in the 83rd minute, and Kamholz tallied UNC's final goal, again a header off a Kluegel corner kick.
Ramsey has come on strong for UNC as of late. She enjoyed one of the best starts to a season of any Tar Heel in history before suffering through a major slump in the middle portion of the year. But with her two goals Sunday, Ramsey now has five goals and two assists in her last five games dating back to an Oct. 29 win against Maryland.
"It's a confidence builder," Ramsey said. "I was starting to get a little frustrated, down in the dumps in the middle of the season. I had, like, goal-block. I couldn't score any goals for like five games.
"So it's definitely helped me out a little bit."
To get the day's news and headlines in your inbox each morning, sign up for our email newsletters.
Her renaissance should provide the Tar Heels with a huge boost as the NCAA tournament progresses.
And although UNC beat a Wake team missing a number of players because of injuries - including second-leading scorer Joline Charlton, who had the game-winning penalty kick against UNC in October - the Tar Heels showed they still know how to step it up in the last phase of the season.
"They're peaking at the right time, obviously through the ACC Tournament and this game," da Luz said. "They're playing at a very, very intense level, a very high level, and it probably bodes well for them in the tournament to run things out.
"And I fully expect them to get through to the final four."
The Sports Editor can be reached at sports@unc.edu.