Marshall will seek the Democratic nomination in 2002 for the Senate seat presently held by Republican Jesse Helms.
Marshall said women in politics, such as herself, are beginning to gain public acceptance.
"It's a quantum leap forward, and women have done well," she said.
"The public is enjoying a growing confidence in women as public policy leaders."
Although she has no experience on the national stage, Marshall has both legislative and executive experience on the state level.
She was elected state senator in 1993, serving just one term. In 1996, Marshall defeated NASCAR driver Richard Petty for her first term as secretary of state -- a post to which she was re-elected last fall.
But Bill Cobey, chairman of the N.C. Republican Party, said name recognition could be a problem for Marshall.
"She has been elected statewide a couple of times," he said. "But she is not very well known. ... It will be hard for her to overcome that."
Marshall is the only Democratic candidate who has officially declared candidacy.