Lido's Bar opened Thursday night under a new manager, Chris Coty, a third-year student at the UNC School of Law.
Coty said he hopes the bar will attract diverse crowds by incorporating different themes on different nights.
Coty said he wants to attract some of the same crowd as The Artist's Escape, which was frequented by lesbians, gays, bisexuals and transgenders but closed last spring.
But he added that he wants to attract a different crowd as well.
"Ideally, Lido's will be a place with variety," Coty said.
"For example, I want Tuesday nights to be trivia nights and Wednesday and Friday to be gay nights. There will be other theme nights, but they have not yet been decided."
But Coty emphasized that he does not want to turn people off from the bar just because of the two nights targeting the LGBT community.
"We are trying to attract everyone," Coty said. "I have seen that Gotham has done well with their gay nights, so we are planning to have a pre-party to Gotham."
Coty is running the bar almost single-handedly, with the volunteer assistance of a few friends.