Chapel Hill police spokeswoman Jane Cousins said police will construct roadblocks around Franklin Street, eliminating parking for a 1 1/2 mile radius.
Cousins said only residents or guests of residents will be allowed to enter the restricted area after police close the perimeter. But she could not pinpoint when exactly the parking restrictions will take effect.
"Estes Road will be closed off," she said. "Everything north of Fordham Boulevard will be closed off. Merritt Mill Road in Carrboro will be closed off."
But Cousins said Manning Drive will remain open for hospital traffic.
The restrictions on travel mean that all public parking facilities in the town will be closed. Bus service also will be suspended.
Police warn that residents trying to enter the restricted area will have to present identification or the precise address of their destination, and illegally parked vehicles will be towed at the owner's expense.
Cousins said this year's efforts are extensive.
"We have additional officers coming in from Durham and all over the state," Cousins said. "Right now, we will have 300 officers on duty total."
Chapel Hill Police Chief Gregg Jarvies said that in addition to the police officers, extra firefighters and public works personnel will be on hand.