The critically acclaimed show, now in its second season, airs Sunday nights and focuses on the experiences of a group of gay people.
Lowell spoke to a group of about 90 people about the show and his experiences as a straight man playing a gay character.
He said he travels to speak to groups because he wants to discuss with the fans the nature of the show and the issues the characters face.
"It's groundbreaking for the gay community," he said. "It's very real, very human and very accurate."
Lowell said the majority of gay actors would not even audition for the role of "Ted" -- or gay roles in general -- because they are afraid of being stigmatized as gay. "There's this fear out there of perception," he said. "Hopefully that's diminishing, and hopefully our show will help that."
Lowell said the producers, Ron Cowen and Dan Lipman, never asked the actors to disclose their sexual preference. "It was not important to Dan and Ron, and it shouldn't be."
Lowell said he did not discuss his sexuality in the press during the first season the show aired because he wanted the acting to speak for itself.
"Hopefully we're doing a good enough of a job that it doesn't matter," Lowell said, saying that the way he and his fellow cast members portray gay characters carries more weight than the actors' own sexuality.
"I understand the curiosity, but who cares?"