Loom2, which opens Saturday, follows a similar exhibit held to great acclaim in December.
"There's a sense of spiritual presence in the building, a religious aura to the space," said senior Jeffrey Waites, the exhibit's creator and co-curator. "I wanted to comment on that, that sense of past life."
The exhibition evokes and pays homage to the 80,000-square-foot Chatham Label Mill and its former inhabitants while infusing the building with a new creative spirit.
Although Waites said this show's premise is similar to the first Loom exhibition, the thematic focus is now on the economy of machine-made and that of handmade goods.
The mill, built in the 1920s, was once the world's leading manufacturer of woven garment labels. It closed in 1996 and is now a national historic site.
Relics from the building's past, such as plans for label designs, will be on display and are incorporated into the artwork. Artists were encouraged to use objects found in the building and surrounding grounds, such as bottles or mop heads, in their pieces.
The building itself serves as a unique display space that interacts with the art. Works crop up in unexpected places, such as in hidden corners and storage rooms and on support pillars.
The building's owner, Tom Roberts, has been an enthusiastic supporter of the project. Waites approached Roberts about two years ago with hopes of transforming the space into an artists' studio, and the Loom exhibits were organized as a way to put the space to creative use in the meantime.
"I think this is a unique opportunity to give artists a chance to show and to give the building exposure as well," Waites said.