But several businesses have opened their doors in the last year looking to make a niche for themselves on a street that hasn't changed its look much in 50 years.
Ralph's Italian Ice, located on Franklin Street next to Wedgie's, has been operating since the summer. Owner Chris Daino brought his idea down from his home in New York.
"We've been very happy with the response," Daino said. "I expected more business from Granville Towers, but we've been pretty good with the students."
Daino said his business has been active in recruiting the highly coveted student buying power.
"We've been advertising every week in the DTH, we donated ice to the Dance Marathon and the Honor Court thing," he said. "Whatever we can do to get kids in, we're doing."
Another new Franklin Street business selling towards students is Classic Contemporary Fashions, located where Emma's Clothing was just last spring.
Owner Drew Chellani said students are keeping him in business.
"(Our business) has been good ever since the students came back," he said. "We're doing mostly student business."
Chellani said he and his staff take careful consideration of what students will want when picking their inventory.