The annual report -- sponsored by the Violence Policy Center, a nonprofit organization based in Washington, D.C. -- focused on the role firearms play in the violence.
According to the report, 10 of the top 15 states identified were located in the South. Mississippi ranked first, with South Carolina third and Tennessee fourth.
It was released in concurrence with Domestic Violence Awareness Month.
The results showed that the majority of female homicides were committed with firearms. In North Carolina, 72 percent of female murder victims were killed with guns in 2000.
Tracy Turner, deputy director of the N.C. Domestic Violence Commission estimated that 40 domestic-violence-related homicides already have been reported in North Carolina this year.
The results were not surprising because the state was ranked in the top 10 for the past two years, said Mary Beth Loucks-Sorrell, interim director of the N.C. Coalition Against Domestic Violence.
The coalition's legislative committee has lobbied for state legislation to mirror federal domestic anti-violence legislation. The federal law prohibits people who have ever been convicted of any domestic violence felony or misdemeanor from ever purchasing firearms.
Sen. Ellie Kinnaird, D-Orange, said there is a large gap between existing state domestic violence laws.
Legislation has been proposed in the N.C. General Assembly that would require criminal background checks for anyone purchasing a gun in any venue, although it has never passed.