The men won their meet 183-100 and the women won 164-123.
The women, who have never lost to the Blue Devils, made it 29 straight wins against their ACC rivals.
The men, who haven't lost since 1939, improved their record to 66-2.
But, not only did UNC win the meet, the men and women won every single event.
Even though the Tar Heels won handily, they treated the meet as a test run for the Nike Cup, which North Carolina will host Nov. 21-23.
"Everybody is looking forward to Nike Cup, so this was kind of a dress rehearsal," co-captain Janna Turner said. "We swam so well; I'm just so impressed with our team. Usually at this meet we don't swim as fast, but today people swam really well. A lot of people went best times."
Allison Herman won the 200-yard butterfly in a personal best time of 2:05.11, and Courtney Lewis did the same thing in the 1,000 freestyle in 10:20.21, just to name a few.
"We wanted to improve our depth, and we wanted to have a very good racing evening, and we did that superbly," UNC coach Frank Comfort said.
But swimming a personal record is not always easy after spending an entire day on campus.