Durham — North Carolina trails Duke by 27 points after 20 minutes of play at Cameron Indoor Stadium, 53-26.
Kyle Singler leads the Blue Devils with 19 points. Nolan Smith has 16, and John Scheyer has 11 points and seven assists.
Tyler Zeller leads UNC with six points on the day while the Tar Heels are shooting just 37 percent from the field.
Duke is out rebounding the Tar Heels 22-12, and Duke is shooting 53.8 percent from beyond the arc.
The last time UNC trailed Duke by a margin this large was Jan. 31, 2002 when the Blue Devils won, 87-58.